A Handbook of Mouse Models of Cardiovascular Disease - download pdf or read online

By Qingbo Xu

ISBN-10: 0470016108

ISBN-13: 9780470016107

ISBN-10: 0470028785

ISBN-13: 9780470028780

The supply of well-defined genetic lines and the power to create transgenic and knockout mice makes mouse types super beneficial biomedical instruments. Their suitability as an experimental approach for cardiovascular learn is determined by the person investigator’s skill to govern the mice surgically. Many mouse types require microsurgical recommendations, which hitherto couldn't be played with out sensible education. This entire guide permits scientists to improve those versions of their personal laboratories.A guide of Mouse versions of Cardiovascular Disease is the 1st booklet to handle pathology in mouse versions of center illness, delivering the reader with crucial info on technical assays in artificially created types. It comprises heritage details on person cardiovascular ailments, describes particular equipment and fabrics used for setting up every one mouse version, discusses the issues that can look within the experiments, and offers examples of functions of the model.A guide of Mouse versions of Cardiovascular Disease:Describes mouse versions of all vital cardiovascular ailments, together with atherosclerosis, atrial traumatic inflammation and thrombosisFeatures movies of key experimental methods at the accompanying CD, permitting researchers to benefit the thoughts by way of at once gazing the full operational procedureDescribes how you can determine every one experimental version with distinct protocols and tips about facing universal operational problemsHighlights power purposes of every version in parts resembling pathogenesis, gene move, therapy and pathophysiologyThis instruction manual is a useful source for researchers in heart problems, pathology, body structure, drawn to the mechanism of vascular issues and healing ways. it's also appropriate to clinicians looking to comprehend the pathology of heart problems and the reason for interventions, and of curiosity to the pharmaceutical and all these inquisitive about drug discovery/development for heart problems.

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Extra info for A Handbook of Mouse Models of Cardiovascular Disease

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Genet 1948; 49: 87–108. 16. Hospital F, Chevalet C, Mulsant P. Using markers in gene introgression breeding programs. Genetics 1992; 132: 1199–1210. 17. Markel P, Shu P, Ebeling C, Carlson GA, Nagle DL, Smutko JS, Moore KJ. Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains. Nat Genet 1997; 17: 280–284. 18. Estrada-Smith D, Castellani LW, Wong H, Wen PZ, Chui A, Lusis AJ, Davis RC. Dissection of multigenic obesity traits in congenic mouse strains. Mamm Genome 2004; 15: 14–22.

From Allayee W, Ghazalpoar A, Lusis AJ. Using mice to dissect genetic factors in atherossclerosis. Arterioscler Thromb Vasc Biol 2003;23:1501; with permission from Lippincott Williams & Wilkins). For a color version of this figure, please see the images supplied on the accompanying CD 28 CH2 NATURALLY OCCURRING VARIATION AMONG MOUSE STRAINS From mouse to man The genes that have been identified through the study of mouse models can be used to identify human homologues. This can be pursued to search for mutations associated with disease in human populations and to identify important pathways involved in disease susceptibility that may lead to development of novel diagnostic and therapeutic strategies.

Genetics 1995; 141: 1199–1207. 33. Linder CC, Davisson MT. Strains, stocks, and mutant mice. In: Hedrich HJ, Bullock G, eds. The Handbook of Experimental Animals – The Laboratory Mouse. Amsterdam: Elsevier, 2004: 25–46. 34. Wakeland E, Morel L, Achey K, Yui M, Longmate J. Speed congenics: a classical technique in the fast lane (relatively speaking). Immunol Today 1997; 18(10): 472–477. 35. Kuhel DG, Zhu B, Witte DP, Hui DY. Distinction in genetic determinants for injuryinduced neointimal hyperplasia and diet-induced atherosclerosis in inbred mice.

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A Handbook of Mouse Models of Cardiovascular Disease by Qingbo Xu

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