Get Biothiols, Part B: Glutathione and Thioredoxin: Thiols in PDF

By John N. Abelson, Melvin I. Simon, Helmut Sies

ISBN-10: 0121821536

ISBN-13: 9780121821531

The significantly acclaimed laboratory common for 40 years, equipment in Enzymology is without doubt one of the so much hugely revered courses within the box of biochemistry. on account that 1955, each one quantity has been eagerlyawaited, often consulted, and praised via researchers and reviewers alike. greater than 250 volumes were released (all of them nonetheless in print) and masses of the cloth is correct even today--truly an important booklet for researchers in all fields of existence sciences. Key positive aspects* Distribution, biosynthesis, metabolism, and shipping of glutathione* sign transduction and gene legislation* Thioredoxin and glutaredoxin* Mimics of organic thiols and thiol inhibitors

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Extra info for Biothiols, Part B: Glutathione and Thioredoxin: Thiols in Signal Transduction and Gene Regulation

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A. 87, 4660 (1990). 44 G. E. Garcia and T. C. Stadtman, J. Bacteriol. 173, 2093 (1991). 45M. J. Berry, L. Banu, J. W. Harnex, and P. R. Larsen, E M B O J. 12, 3315 (1993). 44 GLUTATHIONE [5] proteins maintained up to mammals should deserve more than curiosity, as their mere existence stresses their biological importance. S t r u c t u r e a n d F u n c t i o n of G l u t a t h i o n e P e r o x i d a s e s C o m m o n Features Bovine c G P X has been extensively investigated functionally. 46-49 With the identification of c G P X as a selenoprotein 5° and the determination of its amino acid sequence 26 and three-dimensional (3D) structure, 51 a rather detailed mechanism of action of the enzyme could be proposed 52 which, however, needs to be revised (see below).

286. ~3M. Suthanthiran, M. E. Anderson, V. K. Sharma, and A. Meister, Proc. Natl. Acad. Sci. A. 87, 7185 (1990). 14 A. Meister, Pharmacol. Ther. 51, 155 (1991). 15 O. W. Griffith, in "Glutathione Centennial: Molecular Perspectives and Clinical Implications" (N. Taniguchi, T. Higashi, Y. Sakamoto, and A. ), Chap. 20, p. 285. Academic Press, New York, 1989. 30 6LUTATHIONE [41 transported. 16 Inhibition of GSH synthesis by administration of BSO is currently under study for treatment of drug- and radiation-resistant tumors (see Meister14).

P. Harrison, E M B O J. 5, 1221 (1986). ~2F. Zinoni, A. Birkmann, T. C. Stadtman, and A. B6ck, Proc. Natl. Acad. Sci. A. 83, 4650 (1986). 13 G. C. Mills, J. Biol. Chem. 229, 189 (1957). 14 G. Cohen and P. Hochstein, Biochemistry 2, 1420 (1963). 40 GLUTATHIONE [51 inhibiting protein," a5 now known as phospholipid hydroperoxide glutathione peroxidase (PHGPX). In contrast to the classic cytosolic GPX (cGPX), P H G P X is a monomeric protein of 19 kDa and is intriguing in its ability to reduce hydroperoxidases of esterified phospholipids and cholesterol in biomembranes.

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Biothiols, Part B: Glutathione and Thioredoxin: Thiols in Signal Transduction and Gene Regulation by John N. Abelson, Melvin I. Simon, Helmut Sies


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