By Kurt Faber
This, the 6th variation of the demonstrated textbook on biocatalysis, feeds into undergraduate and graduate classes in sleek natural chemistry, to boot being a concise creation to the sector. New fabric comprises color images and state of the art examine.
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Extra info for Biotransformations
The chiral cyanohydrins also lead directly to a-hydroxy acids by hydrolysis (sequence B)  and to protected a-hydroxy aldehydes by first hydroxyl group protection, followed by reduction of the nitrile and hydrolysis of the intermediate imine (not shown) (sequence C)  By selection of an appropriate derivative the hydroxyl group can become activated towards displacement (via an SN2 exchange process) with a suitably chosen nucleophile. Conversion to the sulfonate ester (SO2R)  promotes displacement by either an acetate (–OAc) (sequence D1) or phthalimide nucleophile (Sequence D2), whilst the trimethylsilyl derivative facilitates introduction of fluorine (Sequence E) .
3 Their Distribution in Nature, Role and Biochemical Characterisation . . . . . . . . . . . . . . . 33 Availability of the Enzymes, Molecular Cloning and Overexpression . . . . . . . . . . . . . . 36 Three Dimensional (3D) Structure . . . . . . . . . 37 3 Enzyme Catalysed Cyanohydrins Reactions . . . . . . . 2 Reaction Mechanism . . . . . . . . . Biocatalytic Transformations, Scope and Limitations (R)-Cyanohydrins .
Biotransformations [1a–c, 2], will be very advantageous. In this respect, the hydroxynitrile lyases (Hnl) and their catalytic production of chiral cyanohydrins may have a significant role to play. The Hnls catalyse the asymmetric addition of hydrogen cyanide (HCN) to the carbonyl moiety of an aldehyde or ketone (Scheme 1) to yield a chiral cyanohydrin (1) (where R1 and R2 R1 = Alkyl or Aryl and R2 = H or Alkyl). Reflecting their role in nature, the cyanohydrin is also cleaved by the HNL to yield HCN and the parent carbonyl compound.
Biotransformations by Kurt Faber