Carbohydrates in Drug Design and Discovery by Jesus Jimenez-Barbero, F. Javier Canada, Sonsoles PDF

By Jesus Jimenez-Barbero, F. Javier Canada, Sonsoles Martin-Santamaria (eds.)

ISBN-10: 1782624732

ISBN-13: 9781782624738

ISBN-10: 1849739390

ISBN-13: 9781849739399

ISBN-10: 1849739994

ISBN-13: 9781849739993

In contemporary years there was expanding facts of the significance of carbohydrates and glycoconjugates in biomedical functions, and using artificial ligands in response to carbohydrates as medications has obtained a lot realization. Focussing on drug discovery from key ambitions and putting an emphasis at the multi-disciplinary ways essential to problem those concerns, this ebook comprehensively covers the hot and up to date discoveries within the sector of carbohydrate drug discovery.

Carbohydrates in Drug layout and Discovery is divided into 5 sections, starting with a advent and point of view at the present marketplace. The booklet then is going directly to talk about new man made tools in glycobiology, using glycobiology in chemical biology and glycobiology in drug discovery.

Providing a global viewpoint in this extensive zone, and delivering examples of therapeutics already constructed utilizing those tools, this booklet presents a entire advent, dialogue and replace in this quickly constructing box for medicinal chemists and biochemists operating in and academia.

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New PDF release: Carbohydrates in Drug Design and Discovery

In recent times there was expanding facts of the significance of carbohydrates and glycoconjugates in biomedical purposes, and using artificial ligands according to carbohydrates as medications has acquired a lot awareness. Focussing on drug discovery from key goals and putting an emphasis at the multi-disciplinary techniques essential to problem those matters, this publication comprehensively covers the recent and up to date discoveries within the sector of carbohydrate drug discovery.

Extra resources for Carbohydrates in Drug Design and Discovery

Example text

Aboitiz, J. Jime ´, P. Groves, J. L. Asensio, D. Andreu, F. J. Can ˜ ada and M. Vila-Perello ´nez-Barbero, ChemBioChem, 2004, 5, 1245–1255. J. 2 In 1943, the pharmacologist Murray J. Shear introduced the current term ‘‘lipopolysaccharide’’, highlighting the glycolipid RSC Drug Discovery Series No. 43 Carbohydrates in Drug Design and Discovery ´nez-Barbero, F. 3 Their protocol of LPS extraction from bacterial dried cells is currently used in the lipopolysaccharide research field. The possibility to use efficient protocols of LPS purification propelled an intensive and highly productive research in all fields of life science, including chemistry, biology, genetics, biophysics, medicine and immunology.

L. Lowary and B. M. Pinto, Bioorg. Med. , 2010, 18, 5123–5128. 46. C. Rademacher, G. K. -S. Kim, R. B. Zheng, H. Taha, C. Liu, R. C. Nacario, D. C. Schriemer, J. S. Klassen, T. Peters and T. L. Lowary, J. Am. Chem. , 2007, 129, 10489–10502. Molecular Basis of Glycan-mediated Host–Pathogen Interactions 37 ¨der, A. Williams, G. Hatch, 47. B. Hamasur, M. Haile, A. Pawlowski, U. Schro ¨ G. Hall, P. Marsh, G. Kallenius and S. B. Svenson, Vaccine, 2003, 21, 4081–4093. 48. T. Nurnberger, F. Brunner, B.

60. A. Canales, J. Angulo, R. Ojeda, M. Bruix, R. Fayos, R. Lozano, ´nez-Gallego, M. Martı´n-Lomas, P. M. Nieto and J. Jime ´nezG. Gime Barbero, J. Am. Chem. , 2005, 127, 5778. ¨lti, P. Egloff, 61. M. Schubert, S. Bleuler-Martinez, A. Butschi, M. A. Wa K. Stutz, S. Yan, I. B. H. Wilson, M. O. Hengartner, M. Aebi, F. H. T. , 2012, 8, e1002706. and M. Ku 62. A. Annila and P. Permi, Concepts Magn. , 2004, 23A, 22. 63. (a) A. Saupe, Angew. , Int. Ed. , 1968, 7, 97; (b) J. A. Losonczi, M. Andrec, M. W.

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Carbohydrates in Drug Design and Discovery by Jesus Jimenez-Barbero, F. Javier Canada, Sonsoles Martin-Santamaria (eds.)


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